US 278 / Mississippi Highway 6 accesses the Natchez Trace Parkway at milepost 256.7. This exit is located in Tupelo, Mississippi.

Starting on August 16, 2023, a 17.5-mile section of the NT Parkway just south of Tupelo, MS will be closed for repaving between mileposts 239.2 and 256.7.

Access to the Parkway heading south at the US 278 / MS Highway 6 intersection is closed.

Click here for more info and a map and directions for both the Marked Detour Route and an Alternate Bicycle Detour Route.

The map below shows the US 278 / Mississippi Highway 6 access / exit to the Natchez Trace Parkway and also nearby attractions, towns and bed and breakfasts.